The resulting decrease in hepatic energy state activates the AMP-activated protein kinase (AMPK), a cellular metabolic sensor, and provided a generally accepted mechanism for metformin action on hepatic gluconeogenic program.

anti-oxidative properties of metformin on endothelial cells.

Decrease hepatic glucose production through a mild inhibition of the mitochondrial respiratory-chain complex 1.

Rachmiel Levine, M.D, Gerald W Sobel, M.D The Mechanism of Action of The Sulfonylureas in Diabetes Mellitus, Diabetes, Volume 6, Issue 3,, Pages 263MECHANISM OF ACTION This paper reviews the drug-target interactions and drug repositioning events of metformin that influences vascular cells and has benefits on angiogenesis-mediated effects.

The relationship between metformin and abnormal miRNA expression has gradually been revealed in the context of numerous diseases and has received increasing attention. Despite its worldwide democratization, owing to its clinical efficacy, high safety profile and cheap cost, the exact mechanism(s) of action of this anti-hyperglycemic molecule with pleiotropic properties still remains to be fully elucidated. MetforminAnti-diabetes medicationBiguanides Metformin is a drug from the biguanide family that is used for decades as the first-line therapeutic choice for the treatment of type 2 diabetes.

anti-oxidative properties of metformin on endothelial cells.Decrease intestinal absorption of glucose.Metformin (1,1-dimethylbiguanide), a biguanide derivate and its chemical structure is related to guanidine.

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